Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones

Journal article

Authors/Editors

Mpadi, Disah

Research Areas

ENGINEERING AND TECHNOLOGY (Frascati classification)

Publication Details

Subtitle: Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones

Author list: Mpadi, Disah

Publisher: Wiley: 12 months

Publication year: 2015

Journal: Journal of Heterocyclic Chemistry (0022-152X)

Volume number: 52

Issue number: 2

Start page: 614

End page: 619

Number of pages: 6

ISSN: 0022-152X

eISSN: 1943-5193

URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jhet.2057

Languages: English-United States (EN-US)

Abstract

The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin-2-ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2-diazo-1,2-diarylethanones, with N-(1-methyl-1H-indol-3-yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, 1H and 13C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity.

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